It ’s such an obvious fact that it hardly feels worth submit , but we all jazz that eat up more calories than you combust makes you gain weight unit , lead to obesity . What is poorly understand , however , is why this often leads to Type 2 diabetes . In an endeavor to get to the bottom of this , a team of researchersfed a mathematical group of volunteers an impressive 6,000 calories a twenty-four hours , and monitored how their body reacted .
There are many health conditions – from centre disease , to diabetes and obesity – that have been linked to gula . It ’s thought that impedance to the hormone insulin , which plays a role in the dead body ’s power to mop up superfluous glucose , is likely a forerunner to the exploitation of diabetes . When your body becomes resistant it still produce the endocrine , but ca n’t take out all the superfluous glucose from your blood stream , which can then go on todamage your kidneysand heart , for example . Thenew study , published in Science Translational Medicine has find a potential mechanism by which this resistance develops .
The small report take six healthy man and fed them up on 6,000 calories of a “ distinctive American ” diet every daytime for a week . This clocks in at around two and a half time what they should normally be eating . The experiment took place at a hospital where the participants were layer hold for the week , not allowed to exercise , and incessantly monitored .
In add-on to gaining a whopping 3.5 kilograms ( 7.7 pounds ) on average during the week , after just two days of gula they started to show signboard of insulin resistance . There have been several hypotheses as to why high - large calorie diets lead to electric resistance , such as too many free butterball acids or firing . But when try by the investigator , neither of these ideas carry true .
When analyzing the participants ' piddle , however , they may have regain a clue . They discovered the Volunteer were egest increasing sum of oxidised compounds , a sign ofoxidative emphasis . An excess of these chemical compound can damage cubicle membranes , and the researchers mistrust that they may be altering the figure of a particular glucose transporter protein , GLUT4 , which sits in the membrane of cells and removes glucose from the blood . This change in shape may affect the protein ’s power to take up glucose when learn to do so by insulin , thus head to insulin resistor .
They then looked at biopsies of rich tissue taken from the participants , and find similar signs of oxidative stress . grant to the researchers , this hint that a treatment that targets oxidative stress and which focus on the GLUT4 protein could be used to treat obesity - colligate insulin impedance .
